Mechanism of Action and Pharmacokinetics Nandrolone Decanoate

Nandrolone is an androgenic anabolic steroid. It is an artificial substance synthetically produced by the pharmaceutical industry, which favors protein synthesis and muscle development.

It acts on calcium metabolism, increasing bone mass, so it is used to fight osteoporosis in certain patients. It is also indicated in certain cases of malnutrition or after some chemotherapy treatments in breast cancer.
Increase strength, speed, aggressiveness and power. «This substance favors performance in blast or strength sports.

Indications

Congenital or acquired primary hypogonadism: When there is testicular insufficiency due to cryptorquedism, bilateral torsion, testicular absence syndrome or orchidoctomy.

Hypogonadotrophic hypogonadism: When there is congenital or acquired deficiency of LH-RH (luteinizing hormone releasing hormone) or hypothalamic hyphoshaemia due to surgeries, traumas, tumors or radiation.

Delayed puberty: When there is a family pattern of late puberty, not secondary to a pathological disorder, in patients who did not respond to supportive psychological therapy.

Climaterio Masculino: As repositora therapy in impotence or other symptoms associated with this disorder, when the etiology is due to a proven androgen deficiency.

Severe malnutrition

Specific anemias: myelofibrous aplastic anemia, myelosclerosis, agnogenic myeloid metaplasia, hypoplastic anemias caused by malignancy or myelotoxic drugs.

Inoperable breast carcinoma: As secondary, tertiary palliative treatment of metastatic breast cancer in women with hormone-receptive tumors or who have demonstrated a previous response to hormonal therapy.

Posology

Hypogonadism, climacteric or impotence (male replacement therapy): 50 to 400 mg I.M. every 2 to 4 weeks.

Puberty male delay (replacement therapy): 25 to 200 mg every 2 to 4 weeks, for a period usually limited to 6 months.

Antineoplastic, in inoperable breast cancer (female): 200 to 400 mg I.M. every 2 to 4 weeks.

Contraindications

It is contraindicated in patients with breast cancer in men, prostate cancer or adenoma diagnosed or suspected, severe heart, liver or kidney failure, in prepubertal individuals or in an aggressive state, pregnancy, hypercalcemia.

Adverse reactions

The following adverse reactions require medical accompaniment:

Virilization and menstrual irregularities in women, irritability of the bladder, gynecomastia. Anaphylaxis, edema, erythrocytosis, gastrointestinal irritation, hypercalcemia and polycythemia, androgenic alopecia, seborrhea and acne in men and women. Carcinoma prostatic hypertrophy and an increase in sexual desire.

They are adverse reactions: Constipation, nausea, diarrhea, infection, redness, pain or irritation at the injection site, alterations in the libido, stomach pain, difficulty in sleep, impotence, testicular atrophy, headaches, anxiety, depression, generalized paraesthesia , sleep apnea, skin rash.

Restrictions of Use

The use of a wet needle or syringe can cause clouding of the solution that does not affect the effectiveness of the medication. If crystals form in the blisters, gentle heating by friction between the hands or agitation can dissolve the crystals.

Intramuscular injection should be administered deeply into the gluteus muscle or deltoid. Do not administer intravenously.

Store at 15-30 ° C and protect from freezing. Shake before using.

Overdose

Treatment in case of overdose: There have been no reports of overdose with the product.